Find medication information including related drug classes, side effects, patient statistics and answers to frequently asked questions. It inhibits the muscarinic receptors in the bladder. Clinical trial agreements a guide to key words and phrases pdf. Objective to describe a 46yearold woman who had memory loss and abnormal memory test results that improved when she discontinued tolterodine therapy. Tolterodine belongs to the group of medicines called antispasmodics.
After oral administration, tolterodine is metabolized in the liver, resulting in the formation of the 5hydroxymethyl derivative, a major pharmacologically active metabolite. Tolterodine tablets bp 2019 these chromatograms are provided for information only as an aid to analysts and are intended as guidance for the interpretation and application of bp monographs. Tolterodine, sold under the brand names detrol among others, is medication used to treat frequent urination, urinary incontinence, or urinary urgency. During this period for solifenacin 5 mg and tolterodine er 4 mg groups respectively 18. Tolterodine tartrate tablets are a prescription medicine for adults used to treat the following symptoms due to a condition called overactive bladder. Additionally, a 23% lower incidence of dry mouth was reported with. Specifically, the medication helps to reduce overactive bladder symptoms, including sudden or frequent urges to urinate, leaking accidents, and frequent urination. What is a patient information leaflet and why is it useful. One month after discontinuing tolterodine therapy, this test was administered a second time using an alternative form and she showed marked improvement scoring above the 75th percentile. Detrusor instability di is a common disorder in children and these children. Signs may include swelling of the hands, face, lips, eyes, tongue, or throat. If you are allergic to any drugs like this one, any other drugs, foods, or other substances. Get medical help right away if you have any of these signs.
Lowdose desmopressin and tolterodine combination therapy for. Serious side effects may include angioedema, urinary retention, and qt prolongation. Tolterodine has a pronounced effect on bladder function. Tolterodine side effects, dosage, interactions drugs. The methods, design and results of this single study have been previously published 10. Tolterodine tartrate synonyms, tolterodine tartrate pronunciation, tolterodine tartrate translation, english dictionary definition of tolterodine tartrate.
Tolterodine is used for the treatment of an overactive bladder. If you have an allergy to tolterodine or any other part of this medicine tolterodine tablets. Urinary tract antispasmodic pregnancy risk category c action competitively antagonizes muscarinic receptors, inhibiting bladder. The elimination halflife of tolterodine for both males and females is 2. This product may contain inactive ingredients, which can cause allergic reactions or other problems. This medication is used to treat an overactive bladder. Tolterodine is used treat overactive bladder a condition in which the bladder muscles contract uncontrollably and cause frequent urination, urgent need to urinate, and inability to control urination. Tolterodine tartrate 2 mg filmcoated tablets patient. Tolterodine was generally well tolerated in clinical trials of up to 24 months duration. Detrol tablets have been approved for the treatment of overactive bladder. Tolterodine works by relaxing the bladder muscles and preventing contractions. Tolterodine is prescribed for the treatment of overactive bladder with symptoms of urge urinary incontinence, urgency, and frequency tolterodine is available under the following different brand names.
After 4 weeks treatment 52% of solifenacin patients and 49% of tolterodine er patients elected to remain. The incidence 40 vs 78%, p tolterodine 2mg twice daily than oxybutynin 5mg 3 times daily. Request pdf clinical differences between solifenacin and tolterodine. The median reduction in these episodes as a percentage of the baseline values was 71% for tolterodine er, 60% for tolterodine ir, and 33%. Before using this medication, tell your doctor or pharmacist your medical history, especially of. Tolterodine tartrate is marketed as a bladderselective anticholinergic drug that is reported to be free of significant cognitive adverse effects. Tolterodine oral detrol side effects, medical uses. Tolterodine medical definition merriamwebster medical. Tolterodine is used to treat symptoms of an overactive bladder, such as incontinence loss of bladder control or a frequent need to urinate. Typical chromatogram for the identification test for tolterodine tablets by thin layer chromatography as published in bp 2019. Tolterodine is in a class of medications called antimuscarinics. Solifenacin significantly improves all symptoms of. It is used in ms to treat overactive bladder, in which the bladder muscles contract uncontrollably and cause urinary frequency, urgency, and incontinence. It works by relaxing the bladder muscles preventing bladder contraction.
These receptors stimulate the bladder muscles to squeeze. A very bad reaction called angioedema has happened with this medicine tolterodine tablets. Tolterodine is available under the following different brand names. A tolterodine 2 mg twice daily active treatment arm was included in one of the four studies, but was not powered for comparison. Overactive bladder oab is characterized by urgency. The 5hydroxymethyl metabolite, which exhibits an antimuscarinic activity similar to that of tolterodine, contributes significantly to the therapeutic effect. Tolterodine may also be used for purposes not listed in this medication guide. Before taking tolterodine, tell your doctor or pharmacist if you are allergic to it. Tolterodine tartrate 2 mg filmcoated tablets patient information leaflet pil by accorduk ltd. It helps decrease muscle spasms of the bladder and the frequent urge to urinate caused by these spasms. Typical chromatogram for the identification test for prolongedrelease tolterodine capsules by thin layer chromatography as published in bp 2019. Tolterodine definition of tolterodine by the free dictionary.
This medicine reduces the amount of bathroom visits. Tolterodine oral capsule, extended release drug summary. The extended release formulation should be swallowed whole. In a study of the effect of tolterodine immediate release tablets on the qt interval see clinical pharmacology 12. It is possible that cognitive dysfunction is a common result of tolterodine treatment, but in the absence of testing, remains undiagnosed. The active moiety, tolterodine, is a muscarinic receptor antagonist. Common side effects include headache, dry mouth, constipation, and dizziness. Cognitive dysfunction with tolterodine use american journal of. Effects of terazosin and tolterodine on ureteral stent.
It is written for patients and gives information about taking or using a medicine. By relaxing the muscles in the bladder, tolterodine improves your ability to control your urination. Trouble passing urine, glaucoma, or slow clearing of the stomach. Pdf solifenacin and tolterodine are equally effective in the. Clinical differences between solifenacin and tolterodine request. This medicine is available only with your doctors prescription. You should not take this medication if you are allergic to tolterodine or fesoterodine toviaz, if you. Dailymed detrol tolterodine tartrate tablet, film coated. Conclusions tolterodine therapy caused cognitive dysfunction in our patient. See what others have said about tolterodine, including the effectiveness, ease of use and side effects.
The patient information leaflet pil is the leaflet included in the pack with a medicine. Tolterodine definition of tolterodine by medical dictionary. H361d suspected of damaging the unborn child precautionary statements. Key words antimuscarinics, desmopressin, nocturia, overactive bladder, tolterodine. Tolterodine tartrate definition of tolterodine tartrate. Tolterodine is used to treat overactive bladder with symptoms of urinary frequency, urgency, and incontinence. For the treatment of overactive bladder oab with symptoms of urge urinary incontinence, urgency, and frequency. Key words anticholinergics, detrusor instability, oxybutynin, tolterodine. Regardless of availability all patients were given the opportunity to request a dose increase.